GAIN-OF-FUNCTION, FOCAL SEGMENTAL GLOMERULOSCLEROSIS TRPC6 MUTATION MINIMALLY AFFECTS SUSCEPTIBILITY TO RENAL INJURY IN SEVERAL MOUSE MODELS

Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models

Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans.Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6.In vitro studies have suggested these mutations affect several signaling pathways, but in vivo studies have largely compared wild-t

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Knowledge of caregivers regarding pneumococcal diseases and pneumococcal conjugate vaccine (PCV): A cross sectional study at a district in India

Background: To reduce burden Folding Chairs of pneumonia, India has introduced Pneumococcal Conjugate vaccine (PCV) in routine immunization programme.The state of West Bengal, India introduced PCV in 2021.Uptake of new vaccines depends a lot on knowledge of caregivers on the disease and vaccine.This study aimed to assess the knowledge of caregivers

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